The Allergy Mold Panel, Complete (Quest) is a serum-based immunoassay panel that measures allergen-specific IgE antibodies directed against a curated set of clinically relevant mold (fungal) allergens, including species such as Alternaria alternata, Aspergillus fumigatus, Cladosporium herbarum, Penicillium notatum, Helminthosporium halodes, and others. Detection of elevated allergen-specific IgE confirms sensitization to one or more mold antigens and supports the diagnosis of mold-triggered allergic rhinitis, allergic asthma, allergic bronchopulmonary aspergillosis (ABPA), or hypersensitivity pneumonitis. This panel is clinically important because mold sensitization is associated with more severe and persistent respiratory allergic disease compared with sensitization to seasonal pollen alone. When a genetically predisposed individual is exposed to mold spores or hyphal fragments, antigen-presenting cells process fungal proteins and drive Th2-skewed immune responses, leading B cells to class-switch and produce allergen-specific IgE antibodies. These IgE molecules bind high-affinity FcεRI receptors on mast cells and basophils; subsequent re-exposure to the same mold antigen cross-links surface-bound IgE, triggering degranulation and release of histamine, leukotrienes, and cytokines that mediate immediate and late-phase allergic symptoms. Chronic mold sensitization can perpetuate airway inflammation, bronchial hyperresponsiveness, and, in susceptible hosts, invasive or semi-invasive fungal disease.
This blood test checks whether your immune system has made allergy antibodies against specific types of mold, helping your doctor identify which molds may be triggering your allergy or asthma symptoms. A positive result means your immune system reacts to that mold, which can guide decisions about avoiding certain environments and whether allergy shots or drops might help.
When elevated: Elevated allergen-specific IgE to one or more mold species confirms sensitization and, in the context of compatible symptoms, supports a diagnosis of mold-triggered allergic rhinitis, allergic asthma, or ABPA. Higher class levels (Class 3–6, ≥3.51 kU/L) generally correlate with greater likelihood of clinical reactivity and may predict more severe or difficult-to-control allergic disease, particularly for Alternaria and Aspergillus sensitization in asthmatic patients. Identification of the specific sensitizing mold(s) guides targeted environmental remediation, avoidance counseling, and allergen immunotherapy selection. When low: Undetectable or very low allergen-specific IgE to all panel components makes IgE-mediated mold allergy unlikely and may prompt evaluation for non-allergic causes of rhinitis, asthma, or recurrent respiratory symptoms. A negative panel does not exclude non-IgE-mediated mold-related disease such as hypersensitivity pneumonitis (which is primarily T-cell and IgG mediated) or toxic mold syndrome. If clinical suspicion remains high despite a negative panel, skin-prick testing, bronchoprovocation, or component-resolved diagnostics may provide additional information.
Mold sensitization can trigger or worsen exercise-induced asthma and allergic rhinitis, both of which impair aerobic performance, recovery quality, and training consistency. Athletes in damp environments (indoor pools, locker rooms, poorly ventilated gyms) or those training outdoors during high mold seasons may benefit from knowing their sensitization status to optimize breathing, reduce inflammation, and prevent performance drops.
Turnaround Time
3 days (up to 7 days)
Fasting Required
No
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Visit a lab service center near you for a quick blood draw (or book at-home phlebotomy where available).
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Your price
$350.00$1050
3.0× less than retail
Versus the typical direct-to-consumer retail price for this test (illustrative — consumer prices vary by provider and region).
$350.00
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