This composite panel combines estimated glomerular filtration rate (eGFR) calculated using both serum creatinine and cystatin C (CKD-EPI 2021 equations) with urine albumin-to-creatinine ratio (uACR) and urine protein-to-creatinine ratio (uPCR) to provide a comprehensive assessment of kidney function and integrity. The dual-biomarker eGFR approach reduces bias associated with muscle mass, diet, and race, offering a more accurate filtration estimate than either marker alone. Together, these parameters allow simultaneous evaluation of glomerular filtration capacity and tubular/glomerular barrier integrity. The glomerular filtration rate reflects the volume of plasma filtered by the kidneys per unit time; creatinine is a muscle-derived waste product freely filtered but also secreted, while cystatin C is a cysteine protease inhibitor produced at a relatively constant rate by all nucleated cells and is freely filtered without tubular secretion, making it less susceptible to non-renal confounders. Albumin and total protein normally appear in urine only in trace amounts due to the selective permeability of the glomerular filtration barrier; elevated urine albumin (albuminuria) reflects glomerular injury, while elevated total protein may additionally indicate tubular dysfunction or overflow proteinuria. The combination of filtration rate and proteinuria markers provides orthogonal information about both the excretory and barrier functions of the nephron.
This panel checks how well your kidneys are filtering waste from your blood and whether they are leaking protein into your urine, which they normally should not do. Two blood proteins—creatinine and cystatin C—are used together to give a more accurate estimate of your kidney filtering rate (eGFR) than either one alone. The urine tests measure albumin and total protein, which can signal early kidney damage even before you feel any symptoms. Together, these results help your doctor determine the health of your kidneys, track any changes over time, and decide if additional evaluation or treatment adjustments are needed. Staying well-hydrated, managing blood pressure and blood sugar, and avoiding nephrotoxic medications are general kidney-health principles, but your doctor will guide any specific recommendations based on your results.
When elevated: Elevated uACR or uPCR with reduced eGFR indicates established CKD with glomerular damage, conferring substantially increased risk for CKD progression to end-stage kidney disease, cardiovascular morbidity, and mortality; higher albuminuria categories independently predict adverse outcomes even with preserved eGFR. When low: A low or undetectable uACR/uPCR combined with a normal or high eGFR is generally reassuring and consistent with preserved kidney function; however, very high eGFR values (>120 mL/min/1.73m²) may occasionally reflect hyperfiltration states (e.g., early diabetic nephropathy, pregnancy, or single-kidney hypertrophy) warranting clinical context.
This panel is most relevant to endurance athletes and those undertaking intense training, as heavy exercise can temporarily elevate creatinine and proteinuria due to increased muscle breakdown and renal perfusion stress. Monitoring eGFR trends and urine protein helps distinguish normal exercise-induced changes from early kidney injury, while the dual-biomarker approach (creatinine + cystatin C) is particularly useful for muscular athletes whose higher muscle mass can skew creatinine-only estimates. For most recreational athletes with stable training, routine kidney screening is lower priority unless there's a history of dehydration, NSAIDs use, or family kidney disease.
Turnaround Time
3 days (up to 7 days)
Method
Kinetic Jaffe, Turbidimetric, Immunoturbidimetric, Spectrophotometric
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Visit a lab service center near you for a quick blood draw (or book at-home phlebotomy where available).
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$45.00$135
3.0× less than retail
Versus the typical direct-to-consumer retail price for this test (illustrative — consumer prices vary by provider and region).
$45.00
Peer-reviewed sources supporting the educational content on this page.
This composite panel combines estimated glomerular filtration rate (eGFR) calculated using both serum creatinine and cystatin C (CKD-EPI 2021 equations) with urine albumin-to-creatinine ratio (uACR) and urine protein-to-creatinine ratio (uPCR) to provide a comprehensive assessment of kidney function and integrity.
This panel checks how well your kidneys are filtering waste from your blood and whether they are leaking protein into your urine, which they normally should not do.
When elevated: Elevated uACR or uPCR with reduced eGFR indicates established CKD with glomerular damage, conferring substantially increased risk for CKD progression to end-stage kidney disease, cardiovascular morbidity, and mortality; higher albuminuria categories independently predict adverse outcomes even with…
The eGFR Creatinine-Cystatin C Calculation With Albumin:Creatinine-Protein:Creatinine Ratios, Urine test starts at $45.00 at Labcorp. No doctor's visit and no insurance needed; we do not bill insurance. Fitomics Insider members pay from $40.00.
Results for the eGFR Creatinine-Cystatin C Calculation With Albumin:Creatinine-Protein:Creatinine Ratios, Urine test are typically ready about 3 days after your draw, and up to 7 days for some samples. Your results land in your Insider portal.
No. When you order the eGFR Creatinine-Cystatin C Calculation With Albumin:Creatinine-Protein:Creatinine Ratios, Urine test from Fitomics Research Labs, a licensed physician in our 50-state network reviews and signs your requisition after checkout, and it lands in your portal and inbox. Then visit any Labcorp, Quest, or BioReference patient service center for your draw; results post to your Insider portal.
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