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Biomarkerkidney urinary

Microalbumin, Urine, Random

Urine microalbumin (random specimen) measures low-level albumin excretion in urine that falls below the detection threshold of conventional urine dipstick protein tests, typically in the range of 30–300 mg/g creatinine when expressed as an albumin-to-creatinine ratio (ACR). It serves as an early, sensitive marker of glomerular endothelial dysfunction and kidney injury, particularly in the context of diabetes mellitus and hypertension. Elevated urinary albumin excretion is independently associated with increased cardiovascular and renal morbidity and mortality. Under normal physiologic conditions, the glomerular filtration barrier restricts passage of albumin (a large, negatively charged protein) into the filtrate, and any small amount that does cross is largely reabsorbed by proximal tubular cells, resulting in urinary albumin excretion below 30 mg/day. Glomerular injury—from hyperglycemia, hypertension, inflammation, or oxidative stress—disrupts the endothelial glycocalyx and podocyte architecture, increasing albumin permeability and urinary losses. Persistent albuminuria reflects systemic endothelial dysfunction and is a surrogate marker of both renal and cardiovascular risk.

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What this test reveals

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This test checks for tiny amounts of a protein called albumin leaking into your urine, which can be an early warning sign that your kidneys are under stress—often from diabetes or high blood pressure. Keeping this level low through good blood sugar and blood pressure control is one of the best ways to protect your kidneys and heart over time.

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What abnormal values may indicate

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When elevated: Persistently elevated urinary albumin (ACR ≥30 mg/g) indicates glomerular injury and is a strong, independent predictor of progressive chronic kidney disease, end-stage renal disease, and major adverse cardiovascular events including myocardial infarction and stroke. In patients with diabetes, moderately increased albuminuria (30–300 mg/g) represents early diabetic nephropathy and signals the need for intensified glycemic and blood pressure management. Values above 300 mg/g (severely increased albuminuria, formerly termed macroalbuminuria or overt proteinuria) are associated with substantially accelerated GFR decline and markedly elevated cardiovascular mortality. When low: Urinary albumin excretion below 30 mg/g is generally reassuring and reflects intact glomerular filtration barrier function in the context of this test. Very low or undetectable albumin levels have no established adverse clinical significance and do not require further evaluation. In patients with known kidney disease who have achieved a reduction in albuminuria through treatment, lower values are associated with slower disease progression and better outcomes.

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For athletes

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Microalbumin is not athlete-specific but matters for long-term health monitoring in active adults. Intense training, dehydration, or underlying metabolic stress can occasionally elevate urinary albumin; persistent elevation warrants evaluation for kidney or cardiovascular strain rather than acute training effects.

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Turnaround Time

4 days (up to 5 days)

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Fasting Required

No

scienceExpected Results

3 results
MICROALBUMIN COMPONENTCreatinine Urine, Timed or RandomAlbumin-creatinine ratio, urine
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How it works

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    Choose your lab and check out. We send your lab requisition automatically — no doctor visit needed.

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    Visit a lab service center near you for a quick blood draw (or book at-home phlebotomy where available).

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    Your results land in your Insider portal, ready to review and act on — that easy.

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Your price

$25.00$75

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3.0× less than retail

Versus the typical direct-to-consumer retail price for this test (illustrative — consumer prices vary by provider and region).

BioReference

$25.00

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References (3)

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Peer-reviewed sources supporting the educational content on this page.

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