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Biomarkerthyroid

Thyroid Panel with TSH

The Thyroid Panel with TSH is a comprehensive set of laboratory tests used to evaluate thyroid gland function, typically including thyroid-stimulating hormone (TSH), free thyroxine (Free T4), and often free triiodothyronine (Free T3). TSH, secreted by the anterior pituitary, serves as the primary screening marker due to its high sensitivity for detecting thyroid dysfunction. Together, these analytes provide a detailed picture of the hypothalamic-pituitary-thyroid (HPT) axis. The thyroid gland produces thyroxine (T4) and triiodothyronine (T3), hormones essential for regulating metabolism, growth, and development across virtually every organ system. TSH is released from the anterior pituitary in response to thyrotropin-releasing hormone (TRH) from the hypothalamus and operates via a classic negative feedback loop: rising thyroid hormone levels suppress TSH secretion, while falling levels stimulate it. Free T4 and Free T3 represent the biologically active, unbound fractions of thyroid hormones and more accurately reflect thyroid hormone availability at the tissue level than total hormone measurements.

From $24.00schedule~8d resultsbiotechAvailable at Quest
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What this test reveals

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The Thyroid Panel with TSH is a blood test that checks how well your thyroid gland is working. Your thyroid is a small gland in your neck that makes hormones controlling your metabolism, energy, and many other body functions. TSH is a hormone made by your brain's pituitary gland that tells the thyroid how much hormone to produce — think of it as a thermostat signal. When TSH is high, it usually means the thyroid is underactive (hypothyroidism), and when it is low, the thyroid may be overactive (hyperthyroidism). The other tests in the panel (Free T4, Free T3) measure the actual thyroid hormones in your blood to give a more complete picture. Your doctor will interpret these results together with your symptoms and medical history.

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What abnormal values may indicate

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When elevated: Elevated TSH with low or low-normal Free T4 is consistent with primary hypothyroidism, indicating insufficient thyroid hormone production. Mildly elevated TSH with normal Free T4 may represent subclinical hypothyroidism. Elevated TSH with elevated Free T4 is rare and may suggest TSH-secreting pituitary adenoma or thyroid hormone resistance. When low: Suppressed or undetectable TSH with elevated Free T4 and/or Free T3 is consistent with overt hyperthyroidism. Low TSH with normal free hormone levels may indicate subclinical hyperthyroidism. Central hypothyroidism (pituitary or hypothalamic origin) can present with low or inappropriately normal TSH alongside low Free T4.

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For athletes

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Thyroid function directly impacts metabolic rate, energy availability, and recovery—critical for athletic performance and training adaptation. Athletes with overtraining syndrome or chronic stress may show TSH elevation or reduced free T4/T3, signaling impaired recovery; conversely, excessive thyroid hormone can increase injury risk and cardiovascular strain. Monitoring this panel helps optimize training load and identify whether fatigue or performance plateaus reflect thyroid dysfunction rather than pure conditioning issues.

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Turnaround Time

8 days (up to 12 days)

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Fasting Required

No

scienceExpected Results

4 results
T3 UptakeT4 (Thyroxine), TotalFree T4 Index (T7)Tsh
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How it works

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    Order online

    Choose your lab and check out. We send your lab requisition automatically — no doctor visit needed.

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    Get your sample collected

    Visit a lab service center near you for a quick blood draw (or book at-home phlebotomy where available).

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    See your results

    Your results land in your Insider portal, ready to review and act on — that easy.

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Your price

$24.00$50

Save ~$26

2.1× less than retail

Versus the typical direct-to-consumer retail price for this test (illustrative — consumer prices vary by provider and region).

Quest

$24.00

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References (3)

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Peer-reviewed sources supporting the educational content on this page.

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