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Biomarkervitamins minerals

Zinc

Zinc is an essential trace element required as a cofactor for over 300 enzymatic reactions and more than 1,000 transcription factors involved in DNA synthesis, cell division, and protein metabolism. It plays a critical role in immune function, wound healing, taste and smell perception, and normal growth and development. Serum or plasma zinc is the most commonly used clinical measure, though it reflects only approximately 0.1% of total body zinc and may not accurately represent intracellular or tissue zinc stores. Zinc is absorbed primarily in the small intestine via zinc transporter proteins (ZIP4 and ZnT5), with absorption regulated by metallothionein and influenced by dietary composition, particularly phytate content. The liver serves as a central regulator of zinc homeostasis, redistributing zinc during acute-phase responses, which can cause serum levels to fall independently of true deficiency. Zinc is excreted predominantly through the gastrointestinal tract, with minor losses via urine, sweat, and other secretions.

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What this test reveals

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Zinc is a mineral your body needs in small amounts to support your immune system, help wounds heal, enable normal growth, and maintain your sense of taste and smell. Most people get enough zinc from a balanced diet that includes meat, shellfish, legumes, and nuts. Low zinc levels can make you more prone to infections and slow healing, while too much zinc—usually from over-supplementation—can interfere with copper absorption and cause other health problems. Blood zinc tests can be affected by many factors such as time of day, recent illness, or low protein levels, so your doctor will consider these alongside your symptoms and diet when interpreting your result.

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What abnormal values may indicate

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When elevated: Elevated serum zinc (hyperzincemia) is most commonly associated with excessive supplementation or occupational exposure rather than dietary intake alone. Chronic zinc excess can competitively inhibit copper absorption, leading to copper deficiency, sideroblastic anemia, and neurological dysfunction including myelopathy. Acute zinc toxicity may cause gastrointestinal symptoms, nausea, and vomiting. When low: Low serum zinc is associated with impaired immune function, increased susceptibility to infections, delayed wound healing, growth retardation in children, hypogonadism, dermatitis, alopecia, and impaired taste and smell (dysgeusia/anosmia). Severe deficiency can cause acrodermatitis enteropathica and profound immune suppression. Marginal deficiency may be subclinical but still contribute to increased infection risk and poor growth outcomes.

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For athletes

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Zinc supports immune function and wound healing—both critical during heavy training when immune stress increases and minor cuts or muscle damage occur. Active individuals who sweat heavily or follow restrictive diets (vegetarian, low-calorie) may have lower zinc status and could benefit from monitoring, as deficiency can impair recovery and increase infection risk.

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Turnaround Time

4 days (up to 14 days)

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Fasting Required

No

scienceExpected Results

1 result
Zinc, Plasma or Serum
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How it works

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    Order online

    Choose your lab and check out. We send your lab requisition automatically — no doctor visit needed.

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    Get your sample collected

    Visit a lab service center near you for a quick blood draw (or book at-home phlebotomy where available).

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    See your results

    Your results land in your Insider portal, ready to review and act on — that easy.

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Your price

$10.90$60

Save ~$49

5.5× less than retail

Versus the typical direct-to-consumer retail price for this test (illustrative — consumer prices vary by provider and region).

QuestBest price

$10.90

Labcorp

$13.90

BioReference

$13.90

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References (3)

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Peer-reviewed sources supporting the educational content on this page.

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